"Update November 15, 2013: A summary of the pathology/necropsy reports from an independent pathologist has determined that the cause of deaths were unrelated to the administration of Trifexis. The summary was derived from the individual pathology/necropsy reports which led attending veterinarians to also conclude that Trifexis was not the cause of death."
When you understand that vaccines lower the immune system for a period of time afterwards it makes sense notnto overload them. I have seen with my own eyes puppies die from vaccines. Children run high fevers and be ill for days after a shot. When done singly the rebound for the immune system Is faster and because immunity doesn't dip as low it is better for the dogs. CDC also thinks flu shots are good for sick people...and those with weakened immune systems. And yet all vaccines say For us in healthy persons (or animals).
They don't work down here. I use comfortis but I wait two weeks and then do the heart worm meds.
In our area trifexis doesn't even really work!